Acitretin is a second-generation retinoid and a metabolite of etretinate. While effective for severe psoriasis, its physical properties are highly dependent on the crystallization process. Because different crystalline structures (polymorphs) can change the drug’s solubility and shelf-life, precise characterization is essential for regulatory compliance and patient safety ( ResearchGate ). 2. Characterization of Polymorphic Forms
Researchers using X-ray powder diffraction (XRPD) and thermal analysis have identified three primary forms: 54757.rar
: Form I can be quantitatively converted into Form II. Acitretin is a second-generation retinoid and a metabolite
The stability of these forms is sensitive to temperature and pressure: 54757.rar