Antimycotic Agent Today

Azoles (e.g., fluconazole, voriconazole) inhibit the enzyme lanosterol 14α-demethylase, preventing the production of ergosterol and weakening the cell membrane.

Many agents, such as polyenes (e.g., Amphotericin B), bind to ergosterol , a sterol unique to fungal membranes, creating pores that cause the cell to leak and die. antimycotic agent

Antimycotic agents function by either killing fungal cells () or inhibiting their growth ( fungistatic ). Because fungal cells are eukaryotic—similar to human cells—developing effective treatments that do not harm the host is a significant challenge. Most agents target unique components of the fungal cell that humans lack: Azoles (e