Keep Garrote and Rupture active on your primary target.
Deathstalker is currently the preferred choice for almost all content due to higher damage and better defenses compared to Fatebound. assassinator
The Assassin Rogue relies on the mechanic to deal devastating "Auto-Crits." Keep Garrote and Rupture active on your primary target
Spend combo points on Envenom to maximize poison damage. assassinator