C4.zip Apr 2026

A C4 ZipTip is a standard pipette tip containing a microscopic bed of resin fixed at its distal end. Unlike C18 resins, which are used for smaller peptides, the C4 resin is optimized for larger, more hydrophobic molecules like proteins and large polypeptides. Primary Uses in Research Researchers use these tools for two main reasons:

This technology has been instrumental in recent studies, including identifying SARS-CoV-2 protease cleavage sites and characterizing human cannabinoid receptors. c4.zip

: Removing salts, buffers, and detergents that interfere with downstream analysis. For example, researchers use them to clean samples of Trastuzumab probes or mussel biotoxins before testing. A C4 ZipTip is a standard pipette tip

: Best for proteins > 10 kDa and highly hydrophobic peptides. : Removing salts, buffers, and detergents that interfere

: The protein sample is aspirated through the tip, binding to the C4 resin.

The C4 ZipTip is most commonly used in the workflow for (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight).

: Contaminants are washed away with a dilute acid, such as trifluoroacetic acid (TFA) .