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Dendritic spines are tiny protrusions on neurons that receive input from other cells. Their size is a direct physical indicator of —larger spines generally correlate with stronger connections. This report examines how these structures change size (structural plasticity), which is a fundamental process underlying learning and memory. 2. Key Findings

Supplemental information, including data sets and molecular models, is also available for download on the same page. Synapses: Changing the size of dendritic spines - eLife

Changes in spine size are closely linked to LTP, a process that strengthens synapses over time. Download 91566

The study investigates the role of specific proteins, including CaMKII (Calmodulin-dependent protein kinase II) and actinin , in managing the structural integrity and growth of the dendritic spine.

Use the button typically located at the top right of the page to save the PDF directly. Dendritic spines are tiny protrusions on neurons that

Mechanisms of Synaptic Strength and Spine Size Regulation Reference: eLife 2023;12:e91566 1. Overview

Download links * Insight. * Structural Biology and Molecular Biophysics. * CaMKII. * actinin. * long-term potentiation. * synapse. The study investigates the role of specific proteins,

Understanding how dendritic spines change size helps researchers decipher the brain's "wiring" and how it stores information. Disruptions in this structural plasticity are often linked to various neurological and cognitive disorders.