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Drug-induced liver injury (DILI), commonly referred to in French medical literature as , involves liver inflammation triggered by exposure to medications, supplements, or herbal products. It is the leading cause of acute liver failure in Western countries and a major reason for withdrawing drugs from the market. 1. Classification and Mechanisms
EASL Clinical Practice Guidelines: Drug-induced liver injury Download Dossier hepatites medicamenteuses pdf
Occurs at therapeutic doses in susceptible individuals due to genetic factors or immune-mediated hypersensitivity. It is harder to predict and may appear weeks or months after starting a treatment. 2. Common Offending Agents Drug-induced liver injury (DILI), commonly referred to in
Over 1,300 substances have been identified as potentially hepatotoxic. The most frequently cited include: Drug-induced liver injury (DILI)
Medical dossiers typically classify these injuries into two main mechanisms:
