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Often causing abdominal discomfort or early satiety.
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Splenic lymphomas remain a diagnostic challenge due to their rarity and overlap with other indolent B-cell neoplasms. Advances in molecular profiling and the success of anti-CD20 monoclonal antibodies have shifted the treatment paradigm away from invasive surgery toward targeted medical therapy. Suggested Resources for PDF Download Often causing abdominal discomfort or early satiety
Anemia or thrombocytopenia due to hypersplenism or bone marrow involvement. Advances in molecular profiling and the success of
Strong association with autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP). 5. Management and Treatment
Splenic lymphomas represent a heterogeneous group of rare B-cell neoplasms primarily involving the spleen, bone marrow, and often the peripheral blood. The most common subtype is Splenic Marginal Zone Lymphoma (SMZL). This paper reviews the clinical presentation, diagnostic criteria (histology and immunophenotype), and evolving therapeutic strategies for these malignancies. 1. Introduction
Now reserved for refractory cases or emergency management of splenic rupture.