It is a standard reagent used to keep G-proteins in a perpetually active state during studies of kinase activity and GPCR (G-protein-coupled receptor) signaling.
Because the protein cannot break down the analog, the G-protein remains locked in its active, bound state. Activation Mechanism: It binds directly to G-protein -subunits. 3. Key Research Applications
-S), a non-hydrolyzable analog of GTP. It is widely used in biochemical research as a . g8634.mp4
Soluble in water, commonly used at high concentrations (e.g., ≥75is greater than or equal to 75 5. Regulatory and Safety Storage Class: 11 (Combustible Solids).
Solutions are very unstable; they must be prepared immediately prior to use. It is a standard reagent used to keep
Requires a dust mask (N95), eyeshields, and gloves. WGK: 3. Source References: Sigma-Aldrich Product Detail PubMed - Cell Signaling Studies Sigma-Aldrich SDS
Used to protect proteins from proteolytic degradation. 4. Stability and Handling The product is sensitive and requires careful handling. Storage: -20°C. Soluble in water, commonly used at high concentrations (e
Used in vitro to induce actin polymerization.