The PDB structure 4WDX reveals the crystal structure of 17 -Hydroxysteroid Dehydrogenase Type 5 (17
-HSD5/AKR1C3) in complex with an inhibitor, providing critical insights into blocking androgen production in castration-resistant prostate cancer. Researchers utilized this structure to map crucial hydrogen bonding with residues like Tyr55 and His117, guiding structure-based drug design for hormone-dependent diseases. Explore the detailed 4WDX data at RCSB Protein Data Bank . ISDA: 4WDX - IBDC
