The Role and Mechanism of Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Nucleoside Reverse Transcriptase Inhibitors (NRTIs) are a foundational class of antiretroviral drugs used primarily in the treatment of HIV-1 infection. Often referred to as "nukes," these agents structurally mimic naturally occurring nucleosides (the building blocks of DNA) to interfere with the viral replication cycle.
Clinically approved NRTIs are frequently used in combination therapies to improve efficacy and reduce the risk of drug resistance. Notable examples include:
