: In a double-blind trial involving women with major depressive disorder, creatine augmentation (5 g/day) of an SSRI led to significantly greater improvements in Hamilton Depression Rating Scale (HAM-D) scores as early as week 2 compared to placebo.
: Evidence from animal models indicates that creatine may interact with the serotonergic system, potentially enhancing the efficacy of medications like Paxil. Clinical Monitoring and Safety Paxil And Creatine
Creatine Activity as a Neuromodulator in the Central Nervous System - PMC : In a double-blind trial involving women with