In the second episode of the Hulu series , the title refers to the gruesome and literal transformation of biological life into something "other".

: The "Freak of the Week," Greg Arkin, transforms into a bug-like creature due to kryptonite exposure. This serves as a dark foil to Clark Kent, who is undergoing his own "metamorphosis" as he discovers more of his alien heritage.

The second episode of uses "Metamorphosis" to mirror the literal transformation of a guest character with the emotional evolution of its leads.

: The narrative deepens around the "Hybrid" project—an attempt to achieve human immortality by transferring human consciousness into synthetic bodies.