Half: [s4e1] Be My Better

: Dr. Connor Rhodes is prepared to leave for a job at the Mayo Clinic, but a surprise donation allows for the creation of a "hybrid suite" in the ED—a project he had championed. It is later revealed that Dr. Ava Bekker secured this funding by making a questionable deal with Connor’s father, Cornelius Rhodes. New Faces at Gaffney

The premiere also introduces two new medical students who challenge the status quo: [S4E1] Be My Better Half

: Following Dr. Will Halstead’s proposal in the season 3 finale, it is confirmed that Dr. Natalie Manning said yes. However, their "engagement bliss" is short-lived; Will pushes for a grand wedding while Natalie prefers something small, leading to early friction in their future plans. Ava Bekker secured this funding by making a

In one of the show's most emotional exits, Dr. Sarah Reese (Rachel DiPillo) officially resigns from the hospital. Her departure is driven by the irreparable damage to her relationship with her mentor, Dr. Daniel Charles, after discovering he nearly let her father die during a heart attack. Natalie Manning said yes

: Tensions remain high between Nurse April Sexton and Dr. Ethan Choi after their breakup. Their relationship is further complicated when Ethan's sister, Emily, is brought into the ED and discovered to be pregnant, sparking a moral debate between Ethan and the pro-life April. A Major Departure: Dr. Sarah Reese

: Following Reese's resignation, Dr. Charles is seen lashing out at a new medical student as he struggles with the guilt and loss of his "daughter-like" mentee. Power Struggles and the Hybrid Suite

The episode's title primarily refers to the long-awaited resolution of the "Manstead" engagement.