George struggles with his guilt after admitting he loves Izzie, while Callie, as Chief Resident, is overwhelmed by her duties and her suspicions that George is cheating.
Meredith and Derek continue their "friends with benefits" arrangement, which Derek eventually admits feels more like an addiction than a healthy relationship. [S4E2] Love/Addiction
Jane Burke returns to the hospital to collect her son Preston's belongings following his departure. Cristina, meanwhile, begins trading her unwanted wedding gifts for surgeries and favors from other doctors. George struggles with his guilt after admitting he
The residents and interns treat victims of a massive apartment fire caused by a meth lab explosion. Alex Karev deals with a particularly difficult case involving a baby who suffered a stroke due to the meth lab environment. as Chief Resident